New patent-pending formula maintained hydration after a single application as participants continued their normal routines, including handwashing

SAN DIEGO, Nov. 4, 2026 /PRNewswire/ — Agency Skin™ today announced the launch of Peptide Renewal Hand Cream™, its first hand cream, which improved hydration for up to 100 hours after a single application in clinical testing. Participants continued their normal daily routines during testing, with no changes to handwashing or skincare.¹

The formula combines a matrix of eight peptides with a blend of five ceramides, cholesterol, and phospholipids modeled on the skin’s own lipid composition. The peptides help visibly reduce the appearance of fine lines and wrinkles on the hands, while the lipid blend helps support the skin’s moisture barrier. Shea butter and squalane help soften rough cuticles and smooth dry hands. The rich cream absorbs quickly without leaving a greasy residue.

“Handwashing is part of everyone’s day, and it’s one reason hands can be hard to keep hydrated,” said Dr. Whitney Tolpinrud, Chief Dermatologist at Agency Skin. “When we tested this formula, we wanted to answer a practical question. How long could one application keep hands hydrated if people kept washing them as often as they usually do?”

Clinical results

• Lasting hydration: A single application helped keep skin moisturized for up to 100 hours.¹
• Improved elasticity: Skin elasticity improved after four weeks of twice-daily use.²
• Healthier-looking nails: After four weeks of twice-daily use, 100% of participants showed healthier-looking nails.³

Agency Skin’s patent-pending formula

Peptide Renewal Hand Cream is designed to address moisture retention, skin texture, and cuticle care through three groups of ingredients:

• Eight-peptide matrix: Helps improve skin elasticity and reduce the appearance of fine lines and wrinkles.
• Skin lipid complex: Combines five ceramides, cholesterol, and phospholipids to help support the skin’s moisture barrier.
• Emollients and humectants: Squalane, shea butter, sodium hyaluronate, jojoba seed oil, and allantoin help attract and retain moisture and soften dry skin and rough cuticles.

Availability and pricing

The launch expands Agency Skin’s non-prescription skincare range beyond facial care. Agency Skin also offers personalized prescription formulas through licensed medical providers.

Peptide Renewal Hand Cream is now available at agencyskin.com for $50. Each tube contains 50 ml / 1.7fl oz.

About Agency Skin™

Agency Skin is a leader in personalized prescription skincare, combining advanced treatments with ongoing care from licensed medical providers. Developed by the Agency Skin team of dermatologists and scientists, every prescription and regimen is designed to address individual needs and support healthy-looking skin and skin longevity. Agency Skin is headquartered in San Diego, CA and serves patients across the United States.

¹ Based on a corneometer measurement in a 35-subject clinical study.

² Based on a clinical study of 35 participants by cutometer measurement after 4 weeks of twice-daily use.

³ Based on a clinical evaluation of 35 participants by an expert grader after 4 weeks of twice-daily use.

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SOURCE Agency Skin